孫承溥 博士
研究助技師
中央研究院 生醫轉譯研究中心
Office: 轉譯中心 B548 (國家生技研究園區)
Office TEL: (02)7750-5500#2564
E-mail: boom@gate.sinica.edu.tw
研究簡介
B型肝炎病毒(HBV)
目前慢性B型肝炎在全世界所造成的人類疾病,仍舊是沉重巨大的公衛負擔 。雖然三十多前開始普遍接種疫苗,目前全球仍然有2億4千萬的B型肝炎病毒帶原病例,在台灣也有近170萬位帶原者,許多B型肝炎患者需要接受抗病毒療法,以免於末期肝病與死亡。但目前的藥物例如干擾素或核苷類似物均無法達到良好的功能性治癒,因此極需要發展新的治療方式。而B型肝炎病毒無法以自然感染方式造成小鼠帶原,藉由生醫所陶秘華研究員的指導,我們建立了數種動物模式,包括B型肝炎病毒基因轉殖鼠、攜帶人類肝臟系統的擬人化小鼠、以及表現類B型肝炎病毒顆粒小鼠等,這些動物模型可供學術界和產業界用於藥物研發。
腺相關病毒載體(Adeno-associated virus)和基因治療
另外我也負責管理陶秘華研究員主持的中研院腺相關病毒載體(AAV, Adeno-associated virus)核心設施。AAV載體為非常有效且快速的研究工具,可了解某一基因的生理功能或基因治療的潛力,而AAV在小鼠表現轉殖基因,可長期表現長達一年以上,因此具有和基因轉殖鼠類似的功能。中研院AAV核心設施不只協助研究人員進行基礎研究將成果發表於國際頂級期刊,也協助國內學界和業界進行AAV藥物開發。
學歷
博士 國立陽明大學 生化暨分子生物研究所
碩士 國立臺灣大學 微生物學研究所
學士 國立臺灣大學 植物病蟲害學系
經歷
2023-迄今 研究助技師 中研院生醫轉譯研究中心
2017-2022 設施經理 中研院腺相關病毒載體核心設施
2013-2017 博士後研究 中研院生醫所
論文著作
- Lee IJ, Lan YH, Wu PY, Wu YW, Chen YH, Tseng SC, Kuo TJ, Sun CP, Jan JT, Ma HH, Liao CC, Liang JJ, Ko HY, Chang CS, Liu WC, Ko YA, Chen YH, Sie ZL, Tsung SI, Lin YL, Wang IH, Tao MH. 2023. A receptor-binding domain-based nanoparticle vaccine elicits durable neutralizing antibody responses against SARS-CoV-2 and variants of concern. Emerg Microbes Infect 12:2149353.
- Huang HC, Wang SH, Fang GC, Chou WC, Liao CC, Sun CP, Jan JT, Ma HH, Ko HY, Ko YA, Chiang MT, Liang JJ, Kuo CT, Lee TA, Morales-Scheihing D, Shen CY, Chen SY, McCullough LD, Cui L, Wernig G, Tao MH, Lin YL, Chang YM, Wang SP, Lai YJ, Li CW. 2023. Upregulation of PD-L1 by SARS-CoV-2 promotes immune evasion. J Med Virol doi:10.1002/jmv.28478.
- Sung PS, Yang SP, Peng YC, Sun CP, Tao MH, Hsieh SL. 2022. CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation. J Biomed Sci 29:52.
- Lee IJ*, Sun CP*, Wu PY, Lan YH, Wang IH, Liu WC, Yuan JP, Chang YW, Tseng SC, Tsung SI, Chou YC, Kumari M, Lin YS, Chen HF, Chen TY, Lin CC, Chiu CW, Hsieh CH, Chuang CY, Cheng CM, Lin HT, Chen WY, Hsu FF, Hong MH, Liao CC, Chang CS, Liang JJ, Ma HH, Chiang MT, Liao HN, Ko HY, Chen LY, Ko YA, Yu PY, Yang TJ, Chiang PC, Hsu ST, Lin YL, Lee CC, Wu HC, Tao MH. 2022. A booster dose of Delta x Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants. J Biomed Sci 29:49. (*Co-First Author)
- Wu CR, Kim HJ, Sun CP, Chung CY, Lin YY, Tao MH, Kim JH, Chen DS, Chen PJ. 2021. Mapping the conformational epitope of a therapeutic monoclonal antibody against HBsAg by in vivo selection of HBV escape variants. Hepatology doi:10.1002/hep.32307.
- Sun CP, Jan JT, Wang IH, Ma HH, Ko HY, Wu PY, Kuo TJ, Liao HN, Lan YH, Sie ZL, Chen YH, Ko YA, Liao CC, Chen LY, Lee IJ, Tsung SI, Lai YJ, Chiang MT, Liang JJ, Liu WC, Wang JR, Yuan JP, Lin YS, Tsai YC, Hsieh SL, Li CW, Wu HC, Ko TM, Lin YL, Tao MH. 2021. Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19. PLoS Pathog 17:e1009758.
- Su SC, Yang TJ, Yu PY, Liang KH, Chen WY, Yang CW, Lin HT, Wang MJ, Lu RM, Tso HC, Chung MJ, Hsieh TY, Chang YL, Lin SC, Hsu FY, Ke FY, Wu YH, Hwang YC, Liu IJ, Liang JJ, Liao CC, Ko HY, Sun CP, Wu PY, Jan JT, Chang YC, Lin YL, Tao MH, Hsu SD, Wu HC. 2021. Structure-guided antibody cocktail for prevention and treatment of COVID-19. PLoS Pathog 17:e1009704.
- Lien CE, Lin YJ, Chen C, Lian WC, Kuo TY, Campbell JD, Traquina P, Lin MY, Liu LT, Chuang YS, Ko HY, Liao CC, Chen YH, Jan JT, Ma HH, Sun CP, Lin YS, Wu PY, Wang YC, Tao MH, Lin YL. 2021. CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge. Sci Rep 11:8761.
- Liang YJ, Teng W, Chen CL, Sun CP, Teng RD, Huang YH, Liang KH, Chen YW, Lin CC, Su CW, Tao MH, Wu JC. 2021. Clinical Implications of HBV PreS/S Mutations and the Effects of PreS2 Deletion on Mitochondria, Liver Fibrosis, and Cancer Development. Hepatology 74:641-655.
- Kulkarni R, Chen WC, Lee Y, Kao CF, Hu SL, Ma HH, Jan JT, Liao CC, Liang JJ, Ko HY, Sun CP, Lin YS, Wang YC, Wei SC, Lin YL, Ma C, Chao YC, Chou YC, Chang W. 2021. Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters. PLoS One 16:e0257191.
- Huang HC, Lai YJ, Liao CC, Yang WF, Huang KB, Lee IJ, Chou WC, Wang SH, Wang LH, Hsu JM, Sun CP, Kuo CT, Wang J, Hsiao TC, Yang PJ, Lee TA, Huang W, Li FA, Shen CY, Lin YL, Tao MH, Li CW. 2021. Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro. EBioMedicine 74:103712.
- Liang YJ, Sun CP, Hsu YC, Chen YW, Wang IA, Su CW, Tao MH, Wu JC. 2020. Statin inhibits large hepatitis delta antigen-Smad3 -twist-mediated epithelial-to-mesenchymal transition and hepatitis D virus secretion. J Biomed Sci 27:65.
- Huang TN, Hsu TT, Lin MH, Chuang HC, Hu HT, Sun CP, Tao MH, Lin JY, Hsueh YP. 2019. Interhemispheric Connectivity Potentiates the Basolateral Amygdalae and Regulates Social Interaction and Memory. Cell Rep 29:34-48 e4.
- Li TN, Wu YJ, Tsai HW, Sun CP, Wu YH, Wu HL, Pei YN, Lu KY, Yen TT, Chang CW, Chan HL, Tao MH, Liou JY, Chang MD, Su IJ, Wang LH. 2018. Intrahepatic hepatitis B virus large surface antigen induces hepatocyte hyperploidy via failure of cytokinesis. J Pathol 245:502-513.
- Lai YH, Sun CP, Huang HC, Chen JC, Liu HK, Huang C. 2018. Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric mice. BMC Complement Altern Med 18:248.
- Chang S, Bok P, Tsai CY, Sun CP, Liu H, Deussing JM, Huang GJ. 2018. NPTX2 is a key component in the regulation of anxiety. Neuropsychopharmacology 43:1943-1953.
- Zhang TY, Yuan Q, Zhao JH, Zhang YL, Yuan LZ, Lan Y, Lo YC, Sun CP, Wu CR, Zhang JF, Zhang Y, Cao JL, Guo XR, Liu X, Mo XB, Luo WX, Cheng T, Chen YX, Tao MH, Shih JW, Zhao QJ, Zhang J, Chen PJ, Yuan YA, Xia NS. 2016. Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen. Gut 65:658-71.
- Chi HC, Chen SL, Tsai CY, Chuang WY, Huang YH, Tsai MM, Wu SM, Sun CP, Yeh CT, Lin KH. 2016. Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy doi:10.1080/15548627.2016.1230583:1-15.
- Chang S, Bok P, Sun CP, Edwards A, Huang GJ. 2016. Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress. PLoS Genet 12:e1006356.
- Shih YM*, Sun CP*, Chou HH, Wu TH, Chen CC, Wu PY, Enya Chen YC, Bissig KD, Tao MH. 2015. Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice. Sci Rep 5:15259. (*Co-First Author)
- Sun CP, Wu TH, Chen CC, Wu PY, Shih YM, Tsuneyama K, Tao MH. 2013. Studies of efficacy and liver toxicity related to adeno-associated virus-mediated RNA interference. Hum Gene Ther 24:739-50.
- Chen CC, Chang CM, Sun CP, Yu CP, Wu PY, Jeng KS, Hu CP, Chen PJ, Wu JC, Shih CH, Gershwin ME, Tao MH. 2012. Use of RNA interference to modulate liver adenoma development in a murine model transgenic for hepatitis B virus. Gene Ther 19:25-33.
- Ju TC, Chen HM, Lin JT, Chang CP, Chang WC, Kang JJ, Sun CP, Tao MH, Tu PH, Chang C, Dickson DW, Chern Y. 2011. Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J Cell Biol 194:209-27.
- Chen CC*, Sun CP*, Ma HI, Fang CC, Wu PY, Xiao X, Tao MH. 2009. Comparative study of anti-hepatitis B virus RNA interference by double-stranded adeno-associated virus serotypes 7, 8, and 9. Mol Ther 17:352-9. (*Co-First Author)