Cell and Tissue Imaging Translational Core (formerly Core Facility of Translational Medicine)
To accelerate biomedical innovation and clinical translational development, the National Biotechnology Research Park has established the “Cell and Tissue Imaging Translation Core”. This facility integrates internationally advanced instruments, interdisciplinary expert teams, and professional technical services to create a one-stop biomedical R&D support platform. The core focuses on key technologies in cellular, genetic, and tissue imaging analysis, providing comprehensive solutions ranging from basic research and mechanistic studies to preclinical validation. It assists academic institutions and the biotech and pharmaceutical industries in accelerating new drug development and technology commercialization.
The Cell and Tissue Imaging Translation Core consists of six key technology platforms:
1, Cell Analysis and Sorting Platform
2, Exosome Purification and Analysis Platform
3, Single-Cell and Spatial Omics Platform
4, Multiscale High-Resolution Imaging Platform
5, Digital Pathology Platform
6, Automated Living Cell Assay Platform
These platforms support three major research directions:
- Immunology and Precision Medicine Applications
This core integrates flow cytometry analysis, cell sorting, single-cell genomics, and exosome technologies to establish a research platform for immunology and precision medicine. Through circulating tumor cells and liquid biopsy approaches, it enables the analysis of tumor characteristics and immune interactions, supporting early detection, treatment monitoring, and biomarker discovery. It also supports the optimization and functional evaluation of cell therapies such as CAR-T, improving clinical translation efficiency and advancing personalized medicine.
- Drug Development and Efficacy Evaluation Applications
By combining automatic living cell assay, high-throughput imaging, and organoid culture systems, a drug screening and functional evaluation platform is established. Using cell and organoid models that simulate the human physiological environment, the system enables drug toxicity and efficacy, improving predictive accuracy. This platform supports candidate drug screening and preclinical testing, and integrates multi-dimensional data to accelerate drug development while reducing risk.
3. Disease Mechanism Analysis and Translational Medicine Applications
This core integrates spatial omics, digital pathology, and advanced imaging technologies to build a cross-scale disease research platform. By integrating tissue imaging with molecular data, it enables the analysis of tumor microenvironments and chronic disease mechanisms, and supports biomarker discovery and precision diagnostics. It also utilizes iPSC and organoid models for personalized drug testing, promoting the translation of basic research into clinical applications and innovative therapies.
For more information, please visit the official website:
https://cti.biotrec.sinica.edu.tw/